Opportunities and challenges for transcriptome-wide association studies
Abstract
Transcriptome-wide association studies (TWAS) integrate genome-wide association studies (GWAS) and gene expression datasets to identify gene-trait associations. In this Perspective, we explore properties of TWAS as a potential approach to prioritize causal genes at GWAS loci, by using simulations and case studies of literature-curated candidate causal genes for schizophrenia, low-density-lipoprotein cholesterol and Crohn's disease. We explore...
Paper Details
Title
Opportunities and challenges for transcriptome-wide association studies
Published Date
Mar 29, 2019
Journal
Volume
51
Issue
4
Pages
592 - 599
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