Nanoparticle Assisted Regulation of Nucleation Pathway of Amyloid Tetramer and Inhibition of Their Fibrillation Kinetics

Low molecular weight (LMW) soluble amyloid oligomers have been established as primary neurotoxic species that play a key role in Alzheimer's disease etiology. However, detection and separation of such energetically unfavored, metastable species are extremely challenging due to their short lifetime and dynamic nature. In this work, the aggregation of amyloid beta has been precisely regulated to produce their tetramer, the most toxic species among...