Luteolin Ameliorates Testis Injury and Blood–Testis Barrier Disruption through the Nrf2 Signaling Pathway and by Upregulating Cx43

Scope Luteolin, a natural flavonoid, displays protective activities to testicular tissue. However, the molecular mechanisms are still unclear. In this study, the aim is to identify the protective effects and underlying mechanisms of luteolin against triptolide (TP)‐induced damage of testicular tissue. Methods and results Pre‐incubation of Sertoli cells (SCs) with luteolin results in a significant reduction of TP‐induced apoptotic cells, which...