Cell biology

Scars

Biology

Biomedical engineering

Surgery

Hypertrophic scar

Scar tissue

Stem cell

Extracellular matrix

Tissue engineering

Regeneration (biology)

Skin repair

Regenerative medicine

Medicine

Regenerative process

Wound healing

Tissue Engineering Part B Reviews

Millions of people every year develop scars in response to skin injuries after surgery, trauma, or burns with significant undesired physical and psychological effects. This review provides an update on engineering strategies for scar-free wound healing and discusses the role of different cell types, growth factors, cytokines, and extracellular components in regenerative wound healing. The use of pro-regenerative matrices combined with engineered cells with less intrinsic potential for fibrogenesis is a promising strategy for achieving scar-free skin tissue regeneration.

Regenerative Scar-Free Skin Wound Healing