Mechanical regulation of myofibroblast phenoconversion and collagen contraction.
Abstract
Activated fibroblasts promote physiological wound repair following tissue injury. However, dysregulation of fibroblast activation contributes to the development of fibrosis by enhanced production and contraction of collagen-rich extracellular matrix. At the peak of their activities, fibroblasts undergo phenotypic conversion into highly contractile myofibroblasts by developing muscle-like features, including formation of contractile actin-myosin...
Paper Details
Title
Mechanical regulation of myofibroblast phenoconversion and collagen contraction.
Published Date
Jun 1, 2019
Journal
Volume
379
Issue
1
Pages
119 - 128
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Notes
History