Dual chemical probes enable quantitative system-wide analysis of protein prenylation and prenylation dynamics.
Abstract
Post-translational farnesylation or geranylgeranylation at a C-terminal cysteine residue regulates the localization and function of over 100 proteins, including the Ras isoforms, and is a therapeutic target in diseases including cancer and infection. Here, we report global and selective profiling of prenylated proteins in living cells enabled by the development of isoprenoid analogues YnF and YnGG in combination with quantitative chemical...
Paper Details
Title
Dual chemical probes enable quantitative system-wide analysis of protein prenylation and prenylation dynamics.
Published Date
Apr 1, 2019
Journal
Volume
11
Issue
6
Pages
552 - 561
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