Sulindac‐derived retinoid X receptor‐α modulator attenuates atherosclerotic plaque progression and destabilization in ApoE−/− mice
Volume: 176, Issue: 14, Pages: 2559 - 2572
Published: May 23, 2019
Abstract
Background and Purpose Atherosclerosis is a chronic inflammatory disease, and retinoid X receptor‐α (RXRα) is an intriguing anti‐atherosclerosis target. This study investigated whether and how an RXRα modulator, K‐80003, derived from a non‐steroidal anti‐inflammatory drug attenuates atherosclerotic plaque progression and destabilization. Experimental Approach Our previously established ApoE −/− mouse model of carotid vulnerable plaque...
Paper Details
Title
Sulindac‐derived retinoid X receptor‐α modulator attenuates atherosclerotic plaque progression and destabilization in ApoE−/− mice
Published Date
May 23, 2019
Volume
176
Issue
14
Pages
2559 - 2572
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