Immunogenomic landscape of hepatocellular carcinoma with immune cell stroma and EBV-positive tumor-infiltrating lymphocytes

•EBV positivity in CD20-positive tumor-infiltrating lymphocytes was present in over 70% of HCC-IS. •HCC-IS lacked CTNNB1 mutations and exhibited increased global DNA hypermethylation. •Both PD-1 and PD-L1 in tumor-infiltrating lymphocytes, and PD-L1 in tumor cells were overexpressed in HCC-IS. •HCCs with high EBV positivity, paradoxically, were associated with a poor prognosis. •HCCs with high EBV positivity exhibited increased levels of...