Clinical use of current polygenic risk scores may exacerbate health disparities.

Volume: 51, Issue: 4, Pages: 584 - 591
Published: Mar 29, 2019
Abstract
Polygenic risk scores (PRS) are poised to improve biomedical outcomes via precision medicine. However, the major ethical and scientific challenge surrounding clinical implementation of PRS is that those available today are several times more accurate in individuals of European ancestry than other ancestries. This disparity is an inescapable consequence of Eurocentric biases in genome-wide association studies, thus highlighting that-unlike...
Paper Details
Title
Clinical use of current polygenic risk scores may exacerbate health disparities.
Published Date
Mar 29, 2019
Volume
51
Issue
4
Pages
584 - 591
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