An interview with Joyce Y Wong: ensuring all voices in biomaterials community are heard.

Published on Mar 27, 2019in Biomedical Materials3.174
· DOI :10.1088/1748-605X/AB08D3
Myron Spector86
Estimated H-index: 86
(Brigham and Women's Hospital)
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Abstract
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2017
1 Author (Jen Roest)
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#1Catherine A. Gormley (BU: Boston University)H-Index: 1
#2Benjamin J. Keenan (BU: Boston University)H-Index: 1
Last. Joyce Y. Wong (BU: Boston University)H-Index: 61
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The development of new therapies for surgical adhesions has proven to be difficult as there is no consistently effective way to assess treatment efficacy in clinical trials without performing a second surgery, which can result in additional adhesions. We have developed lipid microbubble formulations that use a short peptide sequence, CREKA, to target fibrin, the molecule that forms nascent adhesions. These targeted polymerized shell microbubbles (PSMs) are designed to allow ultrasound imaging of...
7 CitationsSource
#1Nae Gyune Rim (BU: Boston University)H-Index: 12
#2Alice Yih (BU: Boston University)H-Index: 1
Last. Joyce Y. Wong (BU: Boston University)H-Index: 61
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Abstract To successfully develop a functional tissue-engineered vascular patch, recapitulating the hierarchical structure of vessel is critical to mimic mechanical properties. Here, we use a cell sheet engineering strategy with micropatterning technique to control structural organization of bovine aortic vascular smooth muscle cell (VSMC) sheets. Actin filament staining and image analysis showed clear cellular alignment of VSMC sheets cultured on patterned substrates. Viability of harvested VSMC...
13 CitationsSource
#1Cari L. Meisel (BU: Boston University)H-Index: 2
#2Polly Bainbridge (BU: Boston University)H-Index: 1
Last. Joyce Y. Wong (BU: Boston University)H-Index: 61
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The impact of the protein-rich in vivo environment on targeted binding of functionalized nanoparticles has been an active field of research over the past several years. Current research aims at better understanding the nature of the protein corona and how it may be possible for targeted binding to occur even in the presence of serum. Much of the current research focuses on nanoparticles targeted to particular cell receptors or features with the aim of cellular uptake. However, similar research h...
4 CitationsSource
#1Olukemi O. Akintewe (BU: Boston University)H-Index: 3
#2Erin G. Roberts (BU: Boston University)H-Index: 5
Last. Joyce Y. Wong (BU: Boston University)H-Index: 61
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Engineered tissues represent an increasingly promising therapeutic approach for correcting structural defects and promoting tissue regeneration in cardiovascular diseases. One of the challenges associated with this approach has been the necessity for the replacement tissue to promote sufficient vascularization to maintain functionality after implantation. This review highlights a number of promising prevascularization design approaches for introducing vasculature into engineered tissues. Althoug...
21 CitationsSource
#1Myron Spector (Brigham and Women's Hospital)H-Index: 86
1 CitationsSource
#1Christopher D. Hartman (BU: Boston University)H-Index: 2
#2Brett C. Isenberg (BU: Boston University)H-Index: 22
Last. Joyce Y. Wong (BU: Boston University)H-Index: 61
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Mechanical compliance has been demonstrated to be a key determinant of cell behavior, directing processes such as spreading, migration, and differentiation. Durotaxis, directional migration from softer to more stiff regions of a substrate, has been observed for a variety of cell types. Recent stiffness mapping experiments have shown that local changes in tissue stiffness in disease are often accompanied by an altered ECM composition in vivo. However, the importance of ECM composition in durotaxi...
67 CitationsSource
#1Stanley Heydrick (BU: Boston University)H-Index: 16
#2Erin G. Roberts (BU: Boston University)H-Index: 5
Last. Joyce Y. Wong (BU: Boston University)H-Index: 61
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Tissue-engineered cardiovascular patches, cardiac valves, and great vessels are emerging solutions for the surgical treatment of congenital cardiovascular abnormalities due to their potential for adapting with the growing child. The ideal pediatric cardiovascular patch/graft is non-thrombogenic, phenotypically compatible, and matches the compliance and mechanical strength of the native tissue, both initially and throughout growth. Bottom-up tissue engineering approaches, in which three-dimension...
5 CitationsSource
#1Chentian Zhang (BU: Boston University)H-Index: 4
#2Elizabeth M. Shenk (BU: Boston University)H-Index: 3
Last. Joyce Y. Wong (BU: Boston University)H-Index: 61
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How metastatic cancer lesions survive and grow in secondary locations is not fully understood. There is a growing appreciation for the importance of tumor components, i.e. microenvironmental cells, in this process. Here, we used a simple microfabricated dual cell culture platform with a 500 μm gap to assess interactions between two different metastatic melanoma cell lines (1205Lu isolated from a lung lesion established through a mouse xenograft; and WM852 derived from a stage III metastatic lesi...
3 CitationsSource
#1Erin G. Roberts (BU: Boston University)H-Index: 5
#2Elaine L. Lee (BU: Boston University)H-Index: 4
Last. Joyce Y. Wong (BU: Boston University)H-Index: 61
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Complex hierarchical organization is a hallmark of tissues and their subsequent integration into organs. A major challenge in tissue engineering is to generate arrays of cells with defined structural organization that display appropriate functional properties. Given what is known about cellular responses to physiochemical cues from the surrounding environment, we can build tissue structures that mimic these microenvironments and validate these platforms using both experimental and computational ...
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