Pesticide

Chemistry

Ecology

Biochemistry

Fungicide

Fatty acid synthase

Propiconazole

Biology

Gene

Lipogenesis

Metabolism

Botany

Lipid metabolism

Zebrafish

Danio

Pharmacology

Journal of Agricultural and Food Chemistry

Propiconazole is a triazole fungicide that has been widely used in agriculture and has been detected in the aquatic environment. This study aimed to investigate the effects of propiconazole exposure on lipid metabolism in the early life stages of zebrafish for 120 h postfertilization (hpf). Using the early life stages of zebrafish to address scientific questions is lower in cost, more efficient, and suitable to meeting current legislation than those in other traditional fish species. Exposure to propiconazole significantly inhibited the development of zebrafish embryos and larvae. This exposure also caused reduced locomotor activities in zebrafish. Furthermore, total cholesterol levels, lipoprotein lipase, and fatty acid synthase activities were significantly decreased. The expression levels of genes involved in lipid metabolism were significantly up-regulated in response to propiconazole exposure. GC-MS/MS analysis revealed that fatty acids were significantly decreased. Together, the findings indicate the potential environmental risks of propiconazole exposure in the aquatic ecosystem.

Effect of Propiconazole on the Lipid Metabolism of Zebrafish Embryos (<i>Danio rerio</i>)

Effect of Propiconazole on the Lipid Metabolism of Zebrafish Embryos (Danio rerio)