Transcriptional repression by androgen receptor: roles in castration-resistant prostate cancer
Abstract
Androgen receptor (AR), a hormonal transcription factor, plays important roles during prostate cancer progression and is a key target for therapeutic interventions. While androgen-deprivation therapies are initially successful in regressing prostate tumors, the disease ultimately comes back as castration-resistant prostate cancer (CRPC) or at the late stage as neuroendocrine prostate cancer (NEPC). CRPC remains largely dependent on hyperactive...
Paper Details
Title
Transcriptional repression by androgen receptor: roles in castration-resistant prostate cancer
Published Date
Jan 1, 2019
Journal
Volume
21
Issue
3
Pages
215 - 215
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