VCAM1 Is Induced in Ovarian Theca and Stromal Cells in a Mouse Model of Androgen Excess

Volume: 160, Issue: 6, Pages: 1377 - 1393
Published: Apr 5, 2019
Abstract
Ovarian theca androgen production is regulated by the pituitary LH and intrafollicular factors. Enhanced androgen biosynthesis by theca cells contributes to polycystic ovary syndrome (PCOS) in women, but the ovarian consequences of elevated androgens are not completely understood. Our study documents the molecular events that are altered in the theca and stromal cells of mice exposed to high androgen levels, using the nonaromatizable androgen...
Paper Details
Title
VCAM1 Is Induced in Ovarian Theca and Stromal Cells in a Mouse Model of Androgen Excess
Published Date
Apr 5, 2019
Volume
160
Issue
6
Pages
1377 - 1393
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