Relaxation‐compensated APT and rNOE CEST‐MRI of human brain tumors at 3 T

Published on Aug 1, 2019in Magnetic Resonance in Medicine4.668
· DOI :10.1002/MRM.27751
Steffen Goerke15
Estimated H-index: 15
(DKFZ: German Cancer Research Center),
Yannick Soehngen1
Estimated H-index: 1
(DKFZ: German Cancer Research Center)
+ 10 AuthorsMark E. Ladd60
Estimated H-index: 60
(DKFZ: German Cancer Research Center)
Sources
Abstract
PURPOSE: Relaxation-compensated CEST-MRI (i.e., the inverse metrics magnetization transfer ratio and apparent exchange-dependent relaxation) has already been shown to provide valuable information for brain tumor diagnosis at ultrahigh magnetic field strengths. This study aims at translating the established acquisition protocol at 7 T to a clinically relevant magnetic field strength of 3 T. METHODS: Protein model solutions were analyzed at multiple magnetic field strengths to assess the spectral widths of the amide proton transfer and relayed nuclear Overhauser effect (rNOE) signals at 3 T. This prior knowledge of the spectral range of CEST signals enabled a reliable and stable Lorentzian-fitting also at 3 T where distinct peaks are no longer resolved in the Z-spectrum. In comparison to the established acquisition protocol at 7 T, also the image readout was extended to three dimensions. RESULTS: The observed spectral range of CEST signals at 3 T was approximately ±15 ppm. Final relaxation-compensated amide proton transfer and relayed nuclear Overhauser effect contrasts were in line with previous results at 7 T. Examination of a patient with glioblastoma demonstrated the applicability of this acquisition protocol in a clinical setting. CONCLUSION: The presented acquisition protocol allows relaxation-compensated CEST-MRI at 3 T with a 3D coverage of the human brain. Translation to a clinically relevant magnetic field strength of 3 T opens the door to trials with a large number of participants, thus enabling a comprehensive assessment of the clinical relevance of relaxation compensation in CEST-MRI.
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References61
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#1Gizeaddis Lamesgin Simegn (UCT: University of Cape Town)H-Index: 1
#2Andre van der Kouwe (Harvard University)H-Index: 44
Last. Ali Alhamud (UCT: University of Cape Town)H-Index: 3
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PURPOSE: CEST MRI allows for indirect detection of molecules with exchangeable protons, measured as a reduction in water signal because of continuous transfer of saturated protons. CEST requires saturation pulses on the order of a second, as well as repeated acquisitions at different offset frequencies. The resulting extended scan time makes CEST susceptible to subject motion, which introduces field inhomogeneity, shifting offset frequencies and causing distortions in CEST spectra that resemble ...
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#1Anagha Deshmane (MPG: Max Planck Society)H-Index: 13
#2Moritz Zaiss (MPG: Max Planck Society)H-Index: 29
Last. Klaus Scheffler (MPG: Max Planck Society)H-Index: 76
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PURPOSE: For clinical implementation, a chemical exchange saturation transfer (CEST) imaging sequence must be fast, with high signal-to-noise ratio (SNR), 3D coverage, and produce robust contrast. However, spectrally selective CEST contrast requires dense sampling of the Z-spectrum, which increases scan duration. This article proposes a compromise: using a 3D snapshot gradient echo (GRE) readout with optimized CEST presaturation, sampling, and postprocessing, highly resolved Z-spectroscopy at 3T...
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#1Ruibin Liu (ZJU: Zhejiang University)H-Index: 3
#3Weiming Niu (ZJU: Zhejiang University)H-Index: 1
Last. Yi Zhang (ZJU: Zhejiang University)H-Index: 19
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PURPOSE: To investigate the effects of frequency drift on chemical exchange saturation transfer (CEST) imaging at 3T, and to propose a new sequence for correcting artifacts attributed to B0 drift in real time. THEORY AND METHODS: A frequency-stabilized CEST (FS-CEST) imaging sequence was proposed by adding a frequency stabilization module to the conventional non-frequency-stabilized CEST (NFS-CEST) sequence, which consisted of a small tip angle radiofrequency excitation pulse and readout of thre...
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#2Peter B. Barker (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 88
#3Robert G. Weiss (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 26
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PURPOSE: To obtain high-resolution Cr and PCr maps of mouse skeletal muscle using a polynomial and Lorentzian line-shape fitting (PLOF) CEST method. METHODS: Wild-type mice and guanidinoacetate N-methyltransferase-deficient (GAMT-/-) mice that have low Cr and PCr concentrations in muscle were used to assign the Cr and PCr peaks in the Z-spectrum at 11.7 T. A PLOF method was proposed to simultaneously extract and quantify the Cr and PCr by assuming a polynomial function for the background and 2 L...
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#1Johannes Windschuh (NYU: New York University)H-Index: 16
#2Moritz Zaiss (MPG: Max Planck Society)H-Index: 29
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PURPOSE: To investigate the effect of a frequency drift of the static magnetic field on 3D CEST MRI based on glycosaminoglycans (GAGs) of articular cartilage at 7 T and to introduce a retrospective correction method that uses the phase images of the gradient-echo readout. METHODS: Repeated gagCEST and B0 measurements were performed in a glucose model solution and in vivo in the knee joint of 3 healthy volunteers at 7 T. Phase images of the modified 3D rectangular spiral centric-reordered gradien...
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#1Moritz Zaiss (MPG: Max Planck Society)H-Index: 29
#2Kai Herz (MPG: Max Planck Society)H-Index: 9
Last. Klaus Scheffler (MPG: Max Planck Society)H-Index: 76
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Abstract Purpose Dynamic CEST studies such as dynamic glucose enhanced imaging, have gained a lot of attention recently. The expected CEST effects after injection are rather small in tissue especially at clinical field strengths (0.5–2%). Small movements during the dynamic CEST measurement together with a subtraction-based evaluation can lead to pseudo CEST effects of the same order of magnitude. These artifacts are studied herein. Methods A brain tumor patient 3D-CEST baseline scan without gluc...
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#1Daniel Paech (DKFZ: German Cancer Research Center)H-Index: 22
#2Johannes Windschuh (DKFZ: German Cancer Research Center)H-Index: 16
Last. Alexander Radbruch (DKFZ: German Cancer Research Center)H-Index: 43
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Background: Early identification of prognostic superior characteristics in glioma patients such as isocitrate dehydrogenase (IDH) mutation and O6-methylguanine-DNA-methyltransferase (MGMT) promoter methylation status is of great clinical importance. The study purpose was to investigate the non-invasive predictability of IDH mutation status, MGMT promoter methylation, and differentiation of low-grade versus high-grade glioma (LGG vs HGG) in newly diagnosed patients employing relaxation-compensate...
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#1Zhongliang Zu (Vandy: Vanderbilt University)H-Index: 22
: Amide proton transfer (APT) imaging is a variation of chemical exchange saturation transfer MRI that has shown promise in diagnosing tumors, ischemic stroke, multiple sclerosis, traumatic brain injury, etc. Specific quantification of the APT effect is crucial for the interpretation of APT contrast in pathologies. Conventionally, magnetization transfer ratio with asymmetric analysis (MTRasym ) has been used to quantify the APT effect. However, some studies indicate that MTRasym is contaminated ...
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// Sebastian Regnery 1, 2 , Sebastian Adeberg 3 , Constantin Dreher 2 , Johanna Oberhollenzer 2 , Jan-Eric Meissner 4 , Steffen Goerke 4 , Johannes Windschuh 4 , Katerina Deike-Hofmann 2 , Sebastian Bickelhaupt 2 , Moritz Zaiss 5 , Alexander Radbruch 2 , Martin Bendszus 6 , Wolfgang Wick 7 , Andreas Unterberg 8 , Stefan Rieken 1 , Jurgen Debus 1 , Peter Bachert 4 , Mark Ladd 4, 9, 10 , Heinz-Peter Schlemmer 2 and Daniel Paech 2 1 Department of Radiation Oncology, University Hospital Heidelberg, ...
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#2Hua Li (Vandy: Vanderbilt University)H-Index: 16
Last. Daniel F. Gochberg (Vandy: Vanderbilt University)H-Index: 36
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PURPOSE: To test the ability of a novel pulse sequence applied in vivo at 3 Tesla to separate the contributions to the water signal from amide proton transfer (APT) and relayed nuclear Overhauser enhancement (rNOE) from background direct water saturation and semisolid magnetization transfer (MT). The lack of such signal source isolation has confounded conventional chemical exchange saturation transfer (CEST) imaging. METHODS: We quantified APT and rNOE signals using a chemical exchange rotation ...
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