TRAILblazing Strategies for Cancer Treatment
Abstract
In the late 1990s, tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), a member of the TNF-family, started receiving much attention for its potential in cancer therapy, due to its capacity to induce apoptosis selectively in tumour cells in vivo. TRAIL binds to its membrane-bound death receptors TRAIL-R1 (DR4) and TRAIL-R2 (DR5) inducing the formation of a death-inducing signalling complex (DISC) thereby activating the...
Paper Details
Title
TRAILblazing Strategies for Cancer Treatment
Published Date
Mar 30, 2019
Journal
Volume
11
Issue
4
Pages
456 - 456
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Notes
History