Migraine

Vasoactive

Receptor

Agonist

Cardiology

Foramen ovale (heart)

Anesthesia

Environmental health

Hypoxemia

Aura

Pediatrics

Migraine Disorders

Mathematics

Patent foramen ovale

Population

Internal medicine

Geometry

Connection (principal bundle)

Medicine

Observational study

Migraine with aura

Sumatriptan

Randomized controlled trial

Neuroimaging Clinics of North America

"Observational studies have identified a relationship between patent foramen ovale (PFO) and migraine headache. In people who have migraine with aura, 40% to 60% have a PFO, compared with 20% to 30% in the general adult population. It is hypothesized that migraine, especially migraine with aura, may be triggered by hypoxemia or vasoactive chemicals (eg, serotonin), which are ordinarily metabolized during passage through the lungs. Although PFO closure is currently not a FDA-approved therapy for migraines, randomized trials suggest that this intervention may benefit a subgroup of migraineurs."

The Connection Between Patent Foramen Ovale and Migraine