Exocrine pancreatic insufficiency: prevalence, diagnosis, and management

Published on Mar 21, 2019in Clinical and Experimental Gastroenterology
路 DOI :10.2147/CEG.S168266
Gabriele Capurso56
Estimated H-index: 56
(UniSR: Vita-Salute San Raffaele University),
M. Traini3
Estimated H-index: 3
(UniSR: Vita-Salute San Raffaele University)
+ 2 AuthorsPaolo Giorgio Arcidiacono42
Estimated H-index: 42
(UniSR: Vita-Salute San Raffaele University)
: Exocrine pancreatic insufficiency (EPI) is a condition caused by reduced or inappropriate secretion or activity of pancreatic juice and its digestive enzymes, pancreatic lipase in particular. EPI can result in clinical manifestation and biochemical alterations causing reduced quality of life and life-threating complications. EPI is common in pancreatic disorders, where it should be suspected and actively investigated, and in many extrapancreatic conditions. There are various tests available to diagnose EPI, with indirect, noninvasive ones, such as concentration of fecal elastase being more commonly employed. Administration of pancreatic enzymes replacement therapy remains the mainstay of EPI treatment. The present review article will discuss current evidence regarding the prevalence of EPI, the available tests to diagnose it and its treatment.
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