Use of UHPLC-QTOF-MS/MS with combination of in silico approach for distributions and metabolites profile of flavonoids after oral administration of Niuhuang Shangqing tablets in rats

Niuhuang Shangqing tablet (NHSQT), a well-known traditional Chinese medicine preparation, has been used as an over- the- counter drug for the treatment of headache, dizziness in China. The flavonoids are the main active components in NHSQT, however, there have no reports about their distribution and metabolic fate in vivo after oral administration of NHSQTs so far. An novel UHPLC-QTOF-MS/MS method combined with in silico approach was applied to...