Salmonella SiiE prevents an efficient humoral immune memory by interfering with IgG + plasma cell persistence in the bone marrow
Volume: 116, Issue: 15, Pages: 7425 - 7430
Published: Mar 25, 2019
Abstract
Serum IgG, which is mainly generated from IgG-secreting plasma cells in the bone marrow (BM), protects our body against various pathogens. We show here that the protein SiiE of Salmonella is both required and sufficient to prevent an efficient humoral immune memory against the pathogen by selectively reducing the number of IgG-secreting plasma cells in the BM. Attenuated SiiE-deficient Salmonella induces high and lasting titers of specific and...
Paper Details
Title
Salmonella SiiE prevents an efficient humoral immune memory by interfering with IgG + plasma cell persistence in the bone marrow
Published Date
Mar 25, 2019
Volume
116
Issue
15
Pages
7425 - 7430
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