RP-18 HPLC Analysis of Drugs’ Ability to Cross the Blood-Brain Barrier

Volume: 2019, Pages: 1 - 12
Published: Mar 27, 2019
Abstract
One hundred ten compounds of diverse structures (actives and excipients used in pharmaceutical preparations) were studied by RP-18 HPLC with acetonitrile-pH 7.4 phosphate buffer 1 : 1 (v/v) as the mobile phase. The relationships between the BBB permeation coefficients and the chromatographic parameters log k and (log k )/PSA were compared to those between the blood-brain barrier (BBB) permeation parameters and the RP-18 TLC descriptors R f and R...
Paper Details
Title
RP-18 HPLC Analysis of Drugs’ Ability to Cross the Blood-Brain Barrier
Published Date
Mar 27, 2019
Volume
2019
Pages
1 - 12
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