PRMT1 loss sensitizes cells to PRMT5 inhibition
Abstract
PRMT5 is an arginine methyltransferase that accounts for the vast majority of the symmetric methylation in cells. PRMT5 exerts its function when complexed with MEP50/WDR77. This activity is often elevated in cancer cells and correlates with poor prognosis, making PRMT5 a therapeutic target. To investigate the PRMT5 signaling pathway and to identify genes whose loss-of-function sensitizes cancer cells to PRMT5 inhibition, we performed a...
Paper Details
Title
PRMT1 loss sensitizes cells to PRMT5 inhibition
Published Date
Mar 27, 2019
Journal
Volume
47
Issue
10
Pages
5038 - 5048
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