Biotechnology

Nanocarriers

Biology

Polyphenol

Drug delivery

Nutraceutical

Biochemistry

Pharmacology

Organic chemistry

Bioavailability

Liposome

Resveratrol

Micelle

Pharmacokinetics

Aqueous solution

Chemistry

Antioxidant

In vivo

International Journal of Molecular Sciences

Resveratrol (3,5,4′-trihydroxystilbene; RSV) is a natural nonflavonoid polyphenol present in many species of plants, particularly in grapes, blueberries, and peanuts. Several in vitro and in vivo studies have shown that in addition to antioxidant, anti-inflammatory, cardioprotective and neuroprotective actions, it exhibits antitumor properties. In mammalian models, RSV is extensively metabolized and rapidly eliminated and therefore it shows a poor bioavailability, in spite it of its lipophilic nature. During the past decade, in order to improve RSV low aqueous solubility, absorption, membrane transport, and its poor bioavailability, various methodological approaches and different synthetic derivatives have been developed. In this review, we will describe the strategies used to improve pharmacokinetic characteristics and then beneficial effects of RSV. These methodological approaches include RSV nanoencapsulation in lipid nanocarriers or liposomes, nanoemulsions, micelles, insertion into polymeric particles, s...

Progress to Improve Oral Bioavailability and Beneficial Effects of Resveratrol