Pseudomonas aeruginosa

Piperacillin

Gram-negative bacterial infections

Imipenem

Biochemistry

Antibiotic resistance

Ceftazidime

Escherichia coli

Microbiology

Aztreonam

Bacteria

Biology

Gene

Ceftazidime/avibactam

Gram-negative bacteria

Avibactam

Antibiotics

Gram

Piperacillin/tazobactam

Tazobactam

Gram-positive bacteria

Beta-Lactamase Inhibitors

Genetics

Medicine

Antimicrobial Agents and Chemotherapy

Metallo-β-lactamase (MBL)-producing Gram-negative bacteria are often extremely resistant, leading to a real therapeutic dead end. Here, we evaluated the in vitro and in vivo efficacy of aztreonam in combination with ceftazidime-avibactam, ceftolozane-tazobactam, or amoxicillin-clavulanate for the treatment of infections caused by MBL-producing Enterobacteriaceae , MBL-producing Pseudomonas aeruginosa , and extremely drug-resistant Stenotrophomonas maltophilia .

Aztreonam plus Clavulanate, Tazobactam, or Avibactam for Treatment of Infections Caused by Metallo-β-Lactamase-Producing Gram-Negative Bacteria