Corpus albicans

Fungemia

Anidulafungin

Candida dubliniensis

Biology

Candida tropicalis

Candida auris

Medicine

Echinocandin

Antifungal

Fluconazole

Candida glabrata

Candida parapsilosis

Micafungin

Caspofungin

Candida albicans

Microbiology

Open Forum Infectious Diseases

The emergence of antifungal resistance threatens effective treatment of invasive fungal infection (IFI). Invasive candidiasis is the most common health care-associated IFI. We evaluated the activity of fluconazole (FLU) against 20 788 invasive isolates of Candida (37 species) collected from 135 medical centers in 39 countries (1997-2016). The activity of anidulafungin, caspofungin, and micafungin (MCF) was evaluated against 15 308 isolates worldwide (2006-2016).Species identification was accomplished using phenotypic (1997-2001), genotypic, and proteomic methods (2006-2016). All isolates were tested using reference methods and clinical breakpoints published in the Clinical and Laboratory Standards Institute documents.A decrease in the isolation of Candida albicans and an increase in the isolation of Candida glabrata and Candida parapsilosis were observed over time. Candida glabrata was the most common non-C. albicans species detected in all geographic regions except for Latin America, where C. parapsilosis an...

Twenty Years of the SENTRY Antifungal Surveillance Program: Results for Candida Species From 1997–2016