Structure of the human LAT1–4F2hc heteromeric amino acid transporter complex
Abstract
The L-type amino acid transporter 1 (LAT1; also known as SLC7A5) catalyses the cross-membrane flux of large neutral amino acids in a sodium- and pH-independent manner1-3. LAT1, an antiporter of the amino acid-polyamine-organocation superfamily, also catalyses the permeation of thyroid hormones, pharmaceutical drugs, and hormone precursors such as L-3,4-dihydroxyphenylalanine across membranes2-6. Overexpression of LAT1 has been observed in a wide...
Paper Details
Title
Structure of the human LAT1–4F2hc heteromeric amino acid transporter complex
Published Date
Mar 13, 2019
Journal
Volume
568
Issue
7750
Pages
127 - 130
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