TRPM2 in Cancer
Abstract
The TRP ion channel TRPM2 has an essential function in cell survival and protects the viability of a number of cell types after oxidative stress. It is highly expressed in many cancers including breast, prostate, and pancreatic cancer, melanoma, leukemia, and neuroblastoma, suggesting it promotes cancer cell survival. TRPM2 is activated by production of ADP-ribose (ADPR) following oxidative stress, which binds to the C-terminus of TRPM2,...
Paper Details
Title
TRPM2 in Cancer
Published Date
Jun 1, 2019
Journal
Volume
80
Pages
8 - 17
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Notes
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