LPS-induced Expression of Monocyte Tissue Factor (TF) Antigen Correlates with Markers of Systemic Inflammation in Patients with Hemophilia A and B

Scientific Research Question: In congenital hemophilia, deficiency in plasma factor VIII or IX activity results in a severely impaired intrinsic amplification loop of blood coagulation. At sites of vascular injury, thrombin generation and fibrin deposition are thus critically dependent on the extrinsic, TF-driven coagulation pathway. Although cytokine-mediated activation of monocytes/macrophages is a hallmark of blood-induced synovitis, no...