Lactate-Mediated Protection of Retinal Ganglion Cells
Abstract
Loss of retinal ganglion cells (RGCs) is a leading cause of blinding conditions. The purpose of this study was to evaluate the effect of extracellular l-lactate on RGC survival facilitated through lactate metabolism and ATP production. We identified lactate as a preferred energy substrate over glucose in murine RGCs and showed that lactate metabolism and consequently increased ATP production are crucial components in promoting RGC survival...
Paper Details
Title
Lactate-Mediated Protection of Retinal Ganglion Cells
Published Date
Apr 1, 2019
Journal
Volume
431
Issue
9
Pages
1878 - 1888
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Notes
History