Melatonergic agonist regulates circadian clock genes and peripheral inflammatory and neuroplasticity markers in patients with depression and anxiety

Volume: 85, Pages: 142 - 151
Published: Mar 1, 2020
Abstract
• Depression and anxiety have been associated with misaligned circadian genes expression. • Disruption of of Immunity and neuroplasticity are associated with sleep disorders. • Melatonergic agonist restores the altered pro-inflammatory cytokines and neurotrophic factors . • The misaligned mRNA expressions of clock genes resynchronized after ramelteon treatment. Circadian dysfunction is a core manifestation and a risk factor for psychiatric...
Paper Details
Title
Melatonergic agonist regulates circadian clock genes and peripheral inflammatory and neuroplasticity markers in patients with depression and anxiety
Published Date
Mar 1, 2020
Volume
85
Pages
142 - 151
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