Duodenal bacterial proteolytic activity determines sensitivity to dietary antigen through protease-activated receptor-2.
Abstract
Microbe-host interactions are generally homeostatic, but when dysfunctional, they can incite food sensitivities and chronic diseases. Celiac disease (CeD) is a food sensitivity characterized by a breakdown of oral tolerance to gluten proteins in genetically predisposed individuals, although the underlying mechanisms are incompletely understood. Here we show that duodenal biopsies from patients with active CeD have increased proteolytic activity...
Paper Details
Title
Duodenal bacterial proteolytic activity determines sensitivity to dietary antigen through protease-activated receptor-2.
Published Date
Mar 13, 2019
Journal
Volume
10
Issue
1
Pages
1198 - 1198
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Notes
History