Effect of the metabolic capacity in rat liver S9 on the positive results of in vitro micronucleus tests
Abstract
A high incidence of positive results is obtained with in vitro genotoxicity tests, which do not correlate with the in vivo negative results in many cases. To address this issue, the metabolic profile of rat liver 9000 × g supernatant fraction (S9) pretreated with phenobarbital (PB) and 5,6-benzoflavone (BNF) was characterized. Furthermore, the in vitro micronucleus tests of 10 compounds were performed with PB-BNF-induced rat S9. PB-BNF increased...
Paper Details
Title
Effect of the metabolic capacity in rat liver S9 on the positive results of in vitro micronucleus tests
Published Date
Jan 1, 2019
Volume
44
Issue
3
Pages
145 - 153
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