Identification of genetic heterogeneity of Alzheimer's disease across age

Volume: 84, Pages: 243.e1 - 243.e9
Published: Dec 1, 2019
Abstract
The risk of APOE for Alzheimer's disease (AD) is modified by age. Beyond APOE, the polygenic architecture may also be heterogeneous across age. We aim to investigate age-related genetic heterogeneity of AD and identify genomic loci with differential effects across age. Stratified gene-based genome-wide association studies and polygenic variation analyses were performed in the younger (60–79 years, N = 14,895) and older (≥80 years, N = 6559)...
Paper Details
Title
Identification of genetic heterogeneity of Alzheimer's disease across age
Published Date
Dec 1, 2019
Volume
84
Pages
243.e1 - 243.e9
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