Pathophysiology

Internal medicine

Pathology

Cardiology

Physical therapy

Pediatrics

Orthostatic intolerance

Tachycardia

Differential diagnosis

Postural Orthostatic Tachycardia Syndrome

Medicine

Orthostatic vital signs

Blood pressure

Physical medicine and rehabilitation

Journal of the American College of Cardiology

Postural orthostatic tachycardia syndrome (POTS), the most common form of orthostatic intolerance in young people, affects approximately 500,000 people in the United States alone, typically young women at the peak of their education and the beginning of their working lives. This is a heterogeneous disorder, the pathophysiology and mechanisms of which are not well understood. There are multiple contributing factors and numerous potential mimics. This review details the most current views on the potential causes, comorbid conditions, proposed subtypes, differential diagnoses, evaluations, and treatment of POTS from cardiological and neurological perspectives.