Anti-PD1 up-regulates PD-L1 expression and inhibits T-cell lymphoma progression: possible involvement of an IFN-γ-associated JAK-STAT pathway.

Volume: 12, Pages: 2079 - 2088
Published: Mar 19, 2019
Abstract
Purpose null NK/T-cell neoplasms are rare, highly aggressive, and insensitive to chemotherapy. These lymphomas have a poor prognosis, with patients being vulnerable to relapse. Hence, there is a need for alternative treatments. The purpose of this study is to investigate whether anti-PD1 takes effect on NK/T cell lymphoma. null Methods null The expression of PD-L1 in NK/T cell lines was investigated by flow cytometry and by Western blot. In...
Paper Details
Title
Anti-PD1 up-regulates PD-L1 expression and inhibits T-cell lymphoma progression: possible involvement of an IFN-γ-associated JAK-STAT pathway.
Published Date
Mar 19, 2019
Volume
12
Pages
2079 - 2088
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