EXPOSURE TO THE CHINESE FAMINE IN EARLY LIFE AND THE THYROID FUNCTION AND NODULES IN ADULTHOOD.

Published on Mar 13, 2019in Endocrine Practice3.443
· DOI :10.4158/EP-2019-0004
Xiaoya Zheng5
Estimated H-index: 5
,
Jian Long3
Estimated H-index: 3
(CQMU: Chongqing Medical University)
+ 4 AuthorsYonghong Wang3
Estimated H-index: 3
Sources
Abstract
ABSTRACT Objective: Previous studies found that exposure to famine was associated with a higher risk of metabolic syndrome and fatty liver in adult women. In the present study, we investigated the ...
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References38
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#1Gustavo Rosa Gentil Andrade (USP: University of São Paulo)H-Index: 2
#2Bartira Mendes Gorgulho (UFMT: Universidade Federal de Mato Grosso)H-Index: 7
Last. Dirce Maria Lobo Marchioni (USP: University of São Paulo)H-Index: 34
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Selenium (Se) participates in several enzymatic reactions necessary for regulating the homeostasis of thyroid hormones. We aimed to analyze the association between dietary Se intake and subclinical hypothyroidism. Baseline data from the Longitudinal Study of Adult Health (Estudo Longitudinal de Saude do Adulto—ELSA-Brasil) in Brazil were analyzed, with a final sample size of 14,283 employees of both sexes aged 35–74 years. Dietary data was collected using a previously validated food frequency qu...
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#1Lærke JohnsenH-Index: 5
#2N B LyckegaardH-Index: 1
Last. Mette O. NielsenH-Index: 27
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Objective We aimed to test, whether fetal under- or overnutrition differentially program the thyroid axis with lasting effects on energy metabolism, and if early-life postnatal overnutrition modulates implications of prenatal programming. Design Twin-pregnant sheep (n = 36) were either adequately (NORM), under- (LOW; 50% of NORM) or overnourished (HIGH; 150% of energy and 110% of protein requirements) in the last-trimester of gestation. From 3 days-of-age to 6 months-of-age, twin lambs received ...
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#2E. Alvarez-SalasH-Index: 6
Last. Patricia de GortariH-Index: 11
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Individuals who consume a diet deficient in zinc (Zn-deficient) develop alterations in hypothalamic-pituitary-thyroid axis function, i.e., a low metabolic rate and cold insensitivity. Although those disturbances are related to primary hypothyroidism, intrauterine or postnatal Zn-deficient adults have an increased thyrotropin (TSH) concentration, but unchanged thyroid hormone (TH) levels and decreased body weight. This does not support the view that the hypothyroidism develops due to a low Zn int...
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The main role of vitamin D is regulating bone metabolism and calcium and phosphorus homeostasis. Over the past few decades, the importance of vitamin D in non-skeletal actions has been studied, including the role of vitamin D in autoimmune diseases, metabolic syndromes, cardiovascular disease, cancers, and all-cause mortality. Recent evidence has demonstrated an association between low vitamin D status and autoimmune thyroid diseases such as Hashimoto’s thyroiditis and Graves’ disease, and impai...
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BACKGROUND: In this study we evaluated whether vitamin B12 deficiency affects neonatal screening (NS) for congenital hypothyroidism (CH). METHODS: A cross-sectional study conducted from 2010 to 2011. A total of 10,740 infants were born in our hospital in this period. Thyroid-stimulating hormone (TSH) was tested for NS and neonates with abnormal screening results (TSH>20 mIU/L) were re-examined. Two hundred and twenty-nine re-called subjects (re-call rate 2.3%) were compared to 77 randomly select...
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#1Dianjun Sun (HMU: Harbin Medical University)H-Index: 1
#2Karen CodlingH-Index: 3
Last. Jun Yan (National Health and Family Planning Commission)H-Index: 2
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The prevention of iodine deficiency through salt iodization has been recognized as a global success story, and China stands at the forefront of this achievement with one of the most successful programs in the world. High level political commitment, national mandatory legislation, a state-managed edible salt industry and a complex and highly sophisticated surveillance system have facilitated the success of the program. Challenges have arisen however, including: (i) concern that adequate iodine st...
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#1Xiaoya Zheng (CQMU: Chongqing Medical University)H-Index: 5
#2Wei Ren (CQMU: Chongqing Medical University)H-Index: 11
Last. Yonghong Wang (CQMU: Chongqing Medical University)H-Index: 3
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Previous studies found famine exposure was associated with a higher risk of metabolic syndrome (MetS). In the study, we investigated the relationship between Chinese famine exposure and the risk of nonalcoholic fatty liver disease (NAFLD) in adult women.Data were obtained from subjects via routine physical examinations in the Public Health Center of our hospital between 2011 and 2014. Women were categorized into the following three groups: control, prenatally exposed, and postnatally exposed. He...
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#1Qian Wu (Xi'an Jiaotong University)H-Index: 11
#2Margaret P. Rayman (University of Surrey)H-Index: 56
Last. Bingying Shi (Xi'an Jiaotong University)H-Index: 1
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Context: Epidemiological studies have supported the premise that an adequate selenium intake is essential for thyroid gland function. Objective: The objective was to investigate whether the prevalence of thyroid disease differed in two areas that were similar, except for very different soil/crop selenium concentrations. Design: Cross-sectional observational study. Setting: The setting was two counties of Shaanxi Province, China, here defined as adequate- and low-selenium. Participants: A total o...
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#1Thomas G. WrightH-Index: 2
#2Brian DawsonH-Index: 71
Last. Kym J. GuelfiH-Index: 28
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Aims: To investigate whether blood thyroid stimulating hormone (TSH), cortisol, insulin and glucose concentrations (plus glucose:insulin ratio; GIR) could improve the accuracy of resting metabolic rate (RMR) prediction in normal, overweight and obese persons. Methods: Predictive equations were developed and compared against indirect calorimetry measures for RMR in 217 weight-control clinic participants (n = 128 males and n = 89 females: ∼24% normal weight, ∼39% overweight and ∼37% obese). Result...
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#1Michael B. Zimmermann (EPFL: École Polytechnique Fédérale de Lausanne)H-Index: 95
#2Kristien Boelaert (University of Birmingham)H-Index: 38
Summary Iodine deficiency early in life impairs cognition and growth, but iodine status is also a key determinant of thyroid disorders in adults. Severe iodine deficiency causes goitre and hypothyroidism because, despite an increase in thyroid activity to maximise iodine uptake and recycling in this setting, iodine concentrations are still too low to enable production of thyroid hormone. In mild-to-moderate iodine deficiency, increased thyroid activity can compensate for low iodine intake and ma...
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The hypothalamus-pituitary-thyroid (HPT) axis regulates energy balance through the pleiotropic action of thyroid hormones. HPT basal activity and stimulation by cold or voluntary exercise are repressed by previous chronic stress in adults. Maternal separation (MS) modifies HPT basal activity, we thus studied the response of the axis to energy demands and analyzed possible epigenetic changes on Trh promoter. Non-handled (NH) or MS male Wistar rats were cold exposed 1h at adulthood, only in NH rat...
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#1Jiahui Guo (PRC: China Medical University (PRC))H-Index: 2
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Background: Malnutrition in early life may permanently change the structure and function of the body, which lead to a number of diseases in adulthood. The effect of famine exposure during the early...
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#1Kelsey Grey (Lond: University of London)H-Index: 1
#2Gerard Bryan Gonzales (WUR: Wageningen University and Research Centre)H-Index: 15
Last. Marko Kerac (Lond: University of London)H-Index: 24
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Introduction Child malnutrition (undernutrition) and adult non-communicable diseases (NCDs) are major global public health problems. While convincing evidence links prenatal malnutrition with increased risk of NCDs, less is known about the long-term sequelae of malnutrition in childhood. We therefore examined evidence of associations between postnatal malnutrition, encompassing documented severe childhood malnutrition in low/middle-income countries (LMICs) or famine exposure, and later-life card...
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