Effects on prostate cancer cells of targeting RNA polymerase III

Volume: 47, Issue: 8, Pages: 3937 - 3956
Published: Mar 1, 2019
Abstract
RNA polymerase (pol) III occurs in two forms, containing either the POLR3G subunit or the related paralogue POLR3GL. Whereas POLR3GL is ubiquitous, POLR3G is enriched in undifferentiated cells. Depletion of POLR3G selectively triggers proliferative arrest and differentiation of prostate cancer cells, responses not elicited when POLR3GL is depleted. A small molecule pol III inhibitor can cause POLR3G depletion, induce similar differentiation and...
Paper Details
Title
Effects on prostate cancer cells of targeting RNA polymerase III
Published Date
Mar 1, 2019
Volume
47
Issue
8
Pages
3937 - 3956
Citation AnalysisPro
  • Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
  • Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.