PTEN influences insulin and lipid metabolism in bovine hepatocytes in vitro
Abstract
Dairy cows with fatty liver or ketosis display decreased insulin sensitivity and defects in the insulin receptor substrate (IRS)/PI3K/AKT signaling pathway. Phosphatase and tensin homolog (PTEN) is a well-known tumor suppressor and also a negative regulator of insulin signaling and peripheral insulin sensitivity. We investigated the hypothesis that PTEN may affect the insulin pathway-mediated hepatic glucose and lipid metabolism in dairy cows....
Paper Details
Title
PTEN influences insulin and lipid metabolism in bovine hepatocytes in vitro
Published Date
Feb 1, 2019
Journal
Volume
86
Issue
1
Pages
73 - 76
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History