Irradiation

Physics

Internal medicine

DNA repair

DNA damage

Radiation sensitivity

PTEN

Biology

Phosphorylation

Ionizing radiation

Nuclear physics

Tyrosine phosphorylation

Glioma

RAD51

Signal transduction

Cell biology

Cancer research

Radiation therapy

Biochemistry

Medicine

PI3K/AKT/mTOR pathway

Cancer Cell

Ma et al. show that ionizing irradiation (IR) induces PTEN Y240 phosphorylation (pY240-PTEN) by FGFR2 in glioblastoma (GBM) cells. pY240-PTEN binds to chromatin and recruits RAD51 to promote DNA repair. Inhibition of Y240 phosphorylation sensitizes GBM to IR and prolongs the survival of GBM preclinical models.

Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair