Posttreatment With the Fatty Acid Amide Hydrolase Inhibitor URB937 Ameliorates One-Lung Ventilation–Induced Lung Injury in a Rabbit Model
Abstract
Background One-lung ventilation (OLV)–induced inflammation is a risk factor for acute lung injury that is responsible for 20% of postoperative pulmonary complications after lung resection. Inflammation is an important trigger for acute lung injury. Fatty acid amide hydrolase (FAAH) is the major enzyme that degrades the endocannabinoid arachidonoylethanolamine (AEA), an important regulator of inflammation, and its downstream metabolites such as...
Paper Details
Title
Posttreatment With the Fatty Acid Amide Hydrolase Inhibitor URB937 Ameliorates One-Lung Ventilation–Induced Lung Injury in a Rabbit Model
Published Date
Jul 1, 2019
Journal
Volume
239
Pages
83 - 91
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