Radionuclide‐Activated Nanomaterials and Their Biomedical Applications

Published on Sep 16, 2019in Angewandte Chemie12.959
· DOI :10.1002/ANIE.201900594
Carolina A. Ferreira17
Estimated H-index: 17
(UW: University of Wisconsin-Madison),
Dalong Ni34
Estimated H-index: 34
(UW: University of Wisconsin-Madison)
+ 1 AuthorsWeibo Cai91
Estimated H-index: 91
(UW: University of Wisconsin-Madison)
Sources
Abstract
: Radio-nanomedicine, or the use of radiolabeled nanoparticles in nuclear medicine, has attracted much attention in the last few decades. Since the discovery of Cerenkov radiation and its employment in Cerenkov luminescence imaging, the combination of nanomaterials and Cerenkov radiation emitters has been revolutionizing the way nanomaterials are perceived in the field: from simple inert carriers of radioactivity to activatable nanomaterials for both diagnostic and therapeutic applications. Herein, we provide a comprehensive review on the types of nanomaterials that have been used to interact with Cerenkov radiation and the gamma and beta scintillation of radionuclides, as well as on their biological applications.
📖 Papers frequently viewed together
225 Citations
76 Citations
48 Citations
References87
Newest
#1Benjamin Cline (UGA: University of Georgia)H-Index: 2
#2Ian Michael Delahunty (UGA: University of Georgia)H-Index: 4
Last. Jin Xie (UGA: University of Georgia)H-Index: 63
view all 3 authors...
Photodynamic therapy (PDT) has emerged as an attractive option for cancer treatment. However, conventional PDT is activated by light that has poor tissue penetration depths, limiting its applicability in the clinic. Recently the idea of using X-ray sources to activate PDT and overcome the shallow penetration issue has garnered significant interest. This can be achieved by external beam irradiation and using a nanoparticle scintillator as transducer. Alternatively, research on exploiting Cherenko...
34 CitationsSource
#1Dalong Ni (UW: University of Wisconsin-Madison)H-Index: 34
#2Emily B. Ehlerding (UW: University of Wisconsin-Madison)H-Index: 20
Last. Weibo Cai (UW: University of Wisconsin-Madison)H-Index: 91
view all 3 authors...
: Positron emission tomography (PET) provides quantitative information in vivo with ultra-high sensitivity but is limited by its relatively low spatial resolution. Therefore, PET has been combined with other imaging modalities, and commercial systems such as PET/computed tomography (CT) and PET/magnetic resonance (MR) have become available. Inspired by the emerging field of nanomedicine, many PET-based multimodality nanoparticle imaging agents have been developed in recent years. This Minireview...
29 CitationsSource
#1Dalong Ni (UW: University of Wisconsin-Madison)H-Index: 34
#2Emily B. Ehlerding (UW: University of Wisconsin-Madison)H-Index: 20
Last. Weibo Cai (UW: University of Wisconsin-Madison)H-Index: 91
view all 3 authors...
4 CitationsSource
#1Dalong Ni (UW: University of Wisconsin-Madison)H-Index: 34
#2Carolina A. Ferreira (UW: University of Wisconsin-Madison)H-Index: 17
Last. Weibo Cai (UW: University of Wisconsin-Madison)H-Index: 91
view all 11 authors...
The interaction between radionuclides and nanomaterials could generate Cerenkov radiation (CR) for CR-induced photodynamic therapy (PDT) without requirement of external light excitation. However, the relatively weak CR interaction leaves clinicians uncertain about the benefits of this new type of PDT. Therefore, a novel strategy to amplify the therapeutic effect of CR-induced PDT is imminently required to overcome the disadvantages of traditional nanoparticulate PDT such as tissue penetration li...
76 CitationsSource
#1Narges Elahi (BMSU: Baqiyatallah University of Medical Sciences)H-Index: 3
#2Mehdi Kamali (BMSU: Baqiyatallah University of Medical Sciences)H-Index: 21
Last. Mohammad Hadi Baghersad (BMSU: Baqiyatallah University of Medical Sciences)H-Index: 4
view all 3 authors...
Abstract Recent advances in nanotechnology are as a result of the development of engineered nanoparticles. Efficiently, metallic nanoparticles have been widely exploited for biomedical application and among them, gold nanoparticles (AuNPs) are highly remarkable. Consequent upon their significant nature, spherical and gold nanorods (Au NRs) nanoparticles attract extreme attention. Their intrinsic features such as optical, electronic, physicochemical and, surface plasmon resonance (SPR); which can...
421 CitationsSource
#1Gang Niu (NIH: National Institutes of Health)H-Index: 1
#2Xiaoyuan Chen (NIH: National Institutes of Health)H-Index: 162
Interaction between radionuclides and nanoparticles expands the in vivo imaging possibilities based on Cerenkov luminescence.
9 CitationsSource
#1Edwin C. Pratt (Cornell University)H-Index: 8
#2Travis M. ShafferH-Index: 11
Last. Jan GrimmH-Index: 55
view all 5 authors...
In biomedical imaging, nanoparticles combined with radionuclides that generate Cerenkov luminescence are used in diagnostic imaging, photon-induced therapies and as activatable probes. In these applications, the nanoparticle is often viewed as a carrier inert to ionizing radiation from the radionuclide. However, certain phenomena such as enhanced nanoparticle luminescence and generation of reactive oxygen species cannot be completely explained by Cerenkov luminescence interactions with nanoparti...
32 CitationsSource
#1Jennifer Lamb (UZH: University of Zurich)H-Index: 2
#2Jason P. Holland (UZH: University of Zurich)H-Index: 30
The advent of hybrid cameras that combine magnetic resonance imaging with either single-photon emission computed tomography (SPECT/MRI) or positron-emission tomography (PET/MRI) has stimulated growing interest in developing multi-modality imaging probes. Countless options are available for fusing magnetically active species with positron- or gamma-ray emitting radionuclides. The initial problem is one of choice: which chemical systems are a suitable basis for developing hybrid imaging agents? An...
53 CitationsSource
#1Dalong Ni (UW: University of Wisconsin-Madison)H-Index: 34
#2Dawei Jiang (UW: University of Wisconsin-Madison)H-Index: 24
Last. Weibo Cai (UW: University of Wisconsin-Madison)H-Index: 91
view all 5 authors...
ConspectusAs one of the most biocompatible and well-tolerated inorganic nanomaterials, silica-based nanoparticles (SiNPs) have received extensive attention over the last several decades. Recently, positron emission tomography (PET) imaging of radiolabeled SiNPs has provided a highly sensitive, noninvasive, and quantitative readout of the organ/tissue distribution, pharmacokinetics, and tumor targeting efficiency in vivo, which can greatly expedite the clinical translation of these promising NPs....
43 CitationsSource
#1Dongban Duan (PKU: Peking University)H-Index: 5
#2Hui Liu (PKU: Peking University)H-Index: 7
Last. Zhibo Liu (PKU: Peking University)H-Index: 21
view all 7 authors...
The classical photodynamic therapy (PDT) requires external light to activate photosensitizers for cancer treatment. However, limited tissue penetration of light has been a long-standing challenge for PDT to cure malignant tumors in deep tissues. Recently, Cerenkov radiation (CR) emitted by radiotracers such as 18F-fluorodeoxyglucose (18F-FDG) has become an alternative and promising internal light source. Nevertheless, fluorine-18 (F-18) only releases 1.3 photons per decay in average; consequentl...
48 CitationsSource
Cited By19
Newest
#1Jingru Guo (CPU: China Pharmaceutical University)
#2Kai Feng (CPU: China Pharmaceutical University)
Last. Xiaolian Sun (CPU: China Pharmaceutical University)H-Index: 37
view all 8 authors...
Stimulating photosensitizers (PS) by Cerenkov radiation (CR) can overcome the light penetration limitation in traditional photodynamic therapy. However, separate injection of radiopharmaceuticals and PS could not guarantee their efficient interaction in tumor areas, while co-delivery of radionuclides and PS face the problem of nonnegligible phototoxicity in normal tissues. Here, we developed a 131 I-labled smart photosensitizer which was composed of pyropheophorbide-a (photosensitizer), diisopro...
Source
#1Giacomo Morselli (UNIBO: University of Bologna)H-Index: 3
#2Marco Villa (UNIBO: University of Bologna)H-Index: 6
Last. Paola Ceroni (UNIBO: University of Bologna)H-Index: 53
view all 5 authors...
Copper indium sulfide (CIS) quantum dots are ideal for bioimaging applications, by being characterized by high molar absorption coefficients throughout the entire visible spectrum, high photoluminescence quantum yield, high tolerance to the presence of lattice defects, emission tunability from the red to the near-infrared spectral region by changing their dimensions and composition, and long lifetimes (hundreds of nanoseconds) enabling time-gated detection to increase signal-to-noise ratio. The ...
Source
#2Nanda RohraH-Index: 1
Last. Rubel Chakravarty (HBNI: Homi Bhabha National Institute)H-Index: 24
view all 11 authors...
ABSTRACT The conventional, chelator-based techniques used for radiolabelling of nanoparticles possess certain shortcomings due to their inherent limitations related to coordination chemistry. These limitations affect their binding with radioisotopes and alter their pharmacokinetics leading to delayed uptake and clearance from the body and possible detachment of radioisotopes during imaging/treatment. These issues have necessitated the development of facile, chelator-free, intrinsic radiolabellin...
1 CitationsSource
#1Nian Liu (TUM: Technische Universität München)H-Index: 5
#2Xiao Chen (LMU: Ludwig Maximilian University of Munich)
Last. Junpeng Shi (CAS: Chinese Academy of Sciences)H-Index: 19
view all 5 authors...
Persistent luminescence nanoparticles (PLNPs) are unique optical materials that emit afterglow luminescence after ceasing excitation. They exhibit unexpected advantages for in vivo optical imaging of tumors, such as autofluorescence-free, high sensitivity, high penetration depth, and multiple excitation sources (UV light, LED, NIR laser, X-ray, and radiopharmaceuticals). Besides, by incorporating other functional molecules, such as photosensitizers, photothermal agents, or therapeutic drugs, PLN...
3 CitationsSource
#1Xuan Zhang (FZU: Fuzhou University)H-Index: 3
#2Qinrui Fu (FZU: Fuzhou University)H-Index: 7
Last. Huanghao Yang (FZU: Fuzhou University)H-Index: 22
view all 5 authors...
Janus nanoparticles (JNPs) refer to the integration of two or more chemically discrepant composites into one structure system. Studies into JNPs have been of significant interest due to their inter...
4 CitationsSource
Radionuclide with Cerenkov radiation (CR) can serve as an internal excitation source to activate photosensitizers for photodynamic therapy (PDT) in deep tumor. However, the low efficiency of CR limits its therapeutic efficacy. A 131 I labeled zinc tetra(4-carboxyphenoxy) phthalocyaninate (ZnPcC4) conjugated Cr3+ -doped zinc gallate (ZnGa2 O4 :Cr3+ , ZGCs) nanoplatform (131 I-ZGCs-ZnPcC4) is developed for radiotherapy (RT) and radiation-induced PDT. 131 I can not only activate ZGCs for long-lasti...
8 CitationsSource
#1Amreen KhanH-Index: 1
#2Faith DiasH-Index: 1
Last. Rohit SrivastavaH-Index: 29
view all 5 authors...
Cancer has been widely investigated yet limited in its manifestation. Cancer treatment holds innovative and futuristic strategies considering high disease heterogeneity. Chemotherapy, radiotherapy and surgery are the most explored pillars; however optimal therapeutic window and patient compliance recruit constraints. Recently evolved immunotherapy demonstrates a vital role of the host immune system to prevent metastasis recurrence, still undesirable clinical response and autoimmune adverse effec...
1 CitationsSource
#1Lile Dong (SYSU: Sun Yat-sen University)H-Index: 2
#2Wenjuan Li (SYSU: Sun Yat-sen University)H-Index: 2
Last. Guobin Hong (SYSU: Sun Yat-sen University)H-Index: 2
view all 6 authors...
Energy-converting biomaterials (ECBs)-mediated cancer-therapeutic modalities have been extensively explored, which have achieved remarkable benefits to overwhelm the obstacles of traditional cancer-treatment modalities. Energy-driven cancer-therapeutic modalities feature their distinctive merits, including noninvasiveness, low mammalian toxicity, adequate therapeutic outcome, and optimistical synergistic therapeutics. In this advanced review, the prevailing mainstream ECBs can be divided into tw...
2 CitationsSource
#1Douglas L. Fritzen (USP: University of São Paulo)H-Index: 1
#2Luidgi Giordano (USP: University of São Paulo)H-Index: 3
Last. Jorge H. S. K. Monteiro (HSU: Humboldt State University)H-Index: 12
view all 4 authors...
The use of luminescence in biological systems allows us to diagnose diseases and understand cellular processes. Persistent luminescent materials have emerged as an attractive system for application in luminescence imaging of biological systems; the afterglow emission grants background-free luminescence imaging, there is no need for continuous excitation to avoid tissue and cell damage due to the continuous light exposure, and they also circumvent the depth penetration issue caused by excitation ...
7 CitationsSource
Cerenkov luminescence imaging and Cerenkov photodynamic therapy have been developed in recent years to exploit the Cerenkov radiation (CR) generated by radioisotopes, frequently used in Nuclear Medicine, to diagnose and fight cancer lesions. For in vivo detection, the endpoint energy of the radioisotope and, thus, the total number of the emitted Cerenkov photons, represents a very important variable and explains why, for example, 68Ga is better than 18F. However, it was also found that the scint...
2 CitationsSource