Voluntary wheel running reduces colon inflammation in female but not male mice fed a high-fat diet

The influence of diet and exercise on intestinal mucus and the spatial organisation of the microbiota is poorly understood. Though, it has been observed that the spatial organisation of the microbiota can be altered extensively in Crohn’s disease and ulcerative colitis. This study aims to investigate the pathophysiological events in mouse colon that are associated with a high fat diet and lack of exercise. Forty-eight, 6-week old C57BL/6NTac...