Hepatic metabolic adaptation in a murine model of glutathione deficiency
Abstract
Glutathione (GSH), the most abundant cellular non-protein thiol, plays a pivotal role in hepatic defense mechanisms against oxidative damage. Despite a strong association between disrupted GSH homeostasis and liver diseases of various etiologies, it was shown that GSH-deficient glutamate-cysteine ligase modifier subunit (Gclm)-null mice are protected against fatty liver development induced by a variety of dietary and environmental insults. The...
Paper Details
Title
Hepatic metabolic adaptation in a murine model of glutathione deficiency
Published Date
Apr 1, 2019
Volume
303
Pages
1 - 6
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