Protein and surface expression of HCN2 and HCN4 subunits in mesocorticolimbic areas after cocaine sensitization
Abstract
The Ih is a mixed depolarizing current present in neurons which, upon activation by hyperpolarization, modulates neuronal excitability in the mesocorticolimbic (MCL) system, an area which regulates emotions such as pleasure, reward, and motivation. Its biophysical properties are determined by HCN protein expression profiles, specifically HCN subunits 1-4. Previously, we reported that cocaine-induced behavioral sensitization increases HCN2...
Paper Details
Title
Protein and surface expression of HCN2 and HCN4 subunits in mesocorticolimbic areas after cocaine sensitization
Published Date
May 1, 2019
Journal
Volume
125
Pages
91 - 98
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Notes
History