The Transcriptional Regulator Sin3A Contributes to the Oncogenic Potential of STAT3
Abstract
Epigenetic silencing of promoter and enhancer regions is a common phenomenon in malignant cells. The transcription factor STAT3 is aberrantly activated in several tumors, where its constitutive acetylation accounts for the transcriptional repression of a number of tumor suppressor genes (TSG) via molecular mechanisms that remain to be understood. Using nucleophosmin-anaplastic lymphoma kinase-positive (NPM-ALK+) anaplastic large-cell lymphoma...
Paper Details
Title
The Transcriptional Regulator Sin3A Contributes to the Oncogenic Potential of STAT3
Published Date
Jun 14, 2019
Journal
Volume
79
Issue
12
Pages
3076 - 3087
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