Identification of Tipifarnib Sensitivity Biomarkers in T-Cell Tumor Cell Lines
Abstract
Background T-cell leukemia and lymphoma (TCL) is a very aggressive and heterogeneous group of hematological malignancies with poor prognosis and inadequate response to current therapies. The standard first-line treatments have resulted in unsatisfactory patient outcomes and unfortunately, targeted treatments are still at a preliminary phase. The RAS/MAPK pathway is crucial for TCR signaling of T-cells and it is deregulated in TCL. We aimed to...
Paper Details
Title
Identification of Tipifarnib Sensitivity Biomarkers in T-Cell Tumor Cell Lines
Published Date
Nov 29, 2018
Journal
Volume
132
Issue
Supplement 1
Pages
2851 - 2851
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Notes
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