Dietary Fatty Acids Fine-Tune Piezo1 Activity

Mechanosensitive ion channels rely on membrane composition to transduce physical stimuli into electrical signals. The Piezo1 channel is a mechanosensitive channel that regulates physiological processes, including vascular architecture and remodeling, cell migration, and erythrocyte volume. Mutations in Piezo1 are associated with dehydrated hereditary stomatocytosis, a hemolytic anemia characterized by increased cation permeability and dehydrated...