Long QT syndrome caveolin‐3 mutations differentially modulate K v 4 and Ca v 1.2 channels to contribute to action potential prolongation
Abstract
Mutations in the caveolae scaffolding protein, caveolin-3 (Cav3), have been linked to the long QT type 9 inherited arrhythmia syndrome (LQT9) and the cause of underlying action potential duration prolongation is incompletely understood. In the present study, we show that LQT9 Cav3 mutations, F97C and S141R, cause mutation-specific gain of function effects on Cav 1.2-encoded L-type Ca2+ channels responsible for ICa,L and also cause loss of...
Paper Details
Title
Long QT syndrome caveolin‐3 mutations differentially modulate K v 4 and Ca v 1.2 channels to contribute to action potential prolongation
Published Date
Jan 24, 2019
Journal
Volume
597
Issue
6
Pages
1531 - 1551
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