Spatially distinct tumor immune microenvironments stratify triple-negative breast cancers

Volume: 129, Issue: 4, Pages: 1785 - 1800
Published: Apr 5, 2019
Abstract
Understanding the tumor immune microenvironment (TIME) promises to be key for optimal cancer therapy, especially in triple-negative breast cancer (TNBC). Integrating spatial resolution of immune cells with laser capture microdissection gene expression profiles, we defined distinct TIME stratification in TNBC, with implications for current therapies including immune checkpoint blockade. TNBCs with an immunoreactive microenvironment exhibited...
Paper Details
Title
Spatially distinct tumor immune microenvironments stratify triple-negative breast cancers
Published Date
Apr 5, 2019
Volume
129
Issue
4
Pages
1785 - 1800
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