Lrp5 and Lrp6 are required for maintaining self‐renewal and differentiation of hematopoietic stem cells
Abstract
Hematopoietic stem cells (HSCs) have the capacity for self-renewal to maintain the HSCs' pool and the ability for multilineage differentiation, which are responsible for sustained production of multiple blood lineages. The regulation of HSC development is controlled precisely by complex signal networks and hematopoietic microenvironment, which has been termed the HSCs' niche. The Wnt signaling pathway is one of a variety of signaling pathways...
Paper Details
Title
Lrp5 and Lrp6 are required for maintaining self‐renewal and differentiation of hematopoietic stem cells
Published Date
Jan 22, 2019
Journal
Volume
33
Issue
4
Pages
5615 - 5625
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