Dose painting by dynamic irradiation delivery on an image-guided small animal radiotherapy platform.

Published on Feb 12, 2019in British Journal of Radiology2.196
· DOI :10.1259/BJR.20180744
Stefan J van Hoof10
Estimated H-index: 10
(UM: Maastricht University),
Joana B Verde1
Estimated H-index: 1
(UM: Maastricht University),
Frank Verhaegen59
Estimated H-index: 59
(UM: Maastricht University)
Objective:Using synchronized three-dimensional stage translation and multiangle radiation delivery to improve conformality and homogeneity of radiation delivery to complexly shaped target volumes f...
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The flexibility and sophistication of modern radiotherapy treatment planning and delivery methods have advanced techniques to improve the therapeutic ratio. Contemporary dose optimization and calculation algorithms facilitate radiotherapy plans which closely conform the three-dimensional dose distribution to the target, with beam shaping devices and image guided field targeting ensuring the fidelity and accuracy of treatment delivery. Ultimately, dose distribution conformity is limited by the ma...
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Many radiotherapy research centers have recently installed novel research platforms enabling the investigation of the radiation response of tumors and normal tissues in small animal models, possibly in combination with other treatment modalities. Many more research institutes are expected to follow in the coming years. These novel platforms are capable of mimicking human radiotherapy more closely than older technology. To facilitate the optimal use of these novel integrated precision irradiators...
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Objective:During precision irradiation of a preclinical lung tumour model, the tumour is subject to breathing motion and it can partially move out of the irradiation field. This work aimed to perform a quantitative analysis of the impact of respiratory motion on a mouse lung tumour irradiation with small fields.Methods:A four-dimensional digital mouse whole body phantom (MOBY) with a virtual 4-mm spherical lung tumour at different locations in both lungs is used to simulate a breathing anaesthet...
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This study was financially supported from Kankeronderzoekfonds Limburg from the Health Foundation Limburg (Star project 2013), EU 7th framework program (Metoxia no. 222741) and from Varian.
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Advances in precision small animal radiotherapy hardware enable the delivery of increasingly complicated dose distributions on the millimeter scale. Manual creation and evaluation of treatment plans becomes difficult or even infeasible with an increasing number of degrees of freedom for dose delivery and available image data. The goal of this work is to develop an optimisation model that determines beam-on times for a given beam configuration, and to assess the feasibility and benefits of an aut...
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PURPOSE Preclinical radiation replicating clinical IMRT techniques can provide data translatable to clinical practice. For this work, treatment plans are created for oxygen-guided dose-painting in small animals utilizing inverse-planned IMRT. Spatially varying beam intensities were achieved using 3D-printed compensators. METHODS AND MATERIALS Optimized beam fluence from arbitrary gantry angles was determined using a verified model of the XRAD225Cx treatment beam. Compensators were 3D-printed wit...
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#1Brent van der Heyden (Maastricht University Medical Centre)H-Index: 7
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X-ray tubes for medical applications typically generate x-rays by accelerating electrons, emitted from a cathode, with an interelectrode electric field, towards an anode target. X-rays are not emitted from one point, but from an irregularly shaped area on the anode, the focal spot. Focal spot intensity distributions and off-focal radiation negatively affect the imaging spatial resolution and broadens the beam penumbra. In this study, a Monte Carlo simulation model of an x-ray tube was developed ...
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#1Hamid Abdollahi (KMU: Kerman Medical University)H-Index: 16
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Abstract Radiotherapy dose painting is a new dose delivery technique to achieve higher treatment outcome. In this approach, does is escalated to high progressive regions which are heterogeneous and determined by advanced medical imaging. Radiomics is issued as a feasible image quantification method to reveal tumor heterogeneity by extraction of high throughput mineable texture features. On the other hand, circadian rhythm is a given biological process that studied as a critical factor to obtain ...
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Abstract Mouse models are essential tools in cancer research that have been used to understand the genetic basis of tumorigenesis, cancer progression and to test the efficacies of anticancer treatments including radiotherapy. They have played a critical role in our understanding of radiotherapy response in tumours and normal tissues and continue to evolve to better recapitulate the underlying biology of humans. In addition, recent developments in small animal irradiators have significantly impro...
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